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Pronounced as “gwaa-hee-oh“, guajillo is hotter than ancho chili powder and brings a spicy kick that ranges from 2,500 to 5,000 SHU. Apart from its spicy taste, this substitute has a lot more going on in flavor than cayenne. It is pleasingly sharp, tangy, and smoky just like paprika. That is why it’s also a good substitute for both hot and smoked paprika.

Because paprika and cayenne come from peppers, both can technically trace their roots back to the Americas. However, the two spices don’t come from the same kind of pepper—nor are they prepared the same way.

What Is Paprika Used For?​